Indications for use drugs: a state here shock - treatment of hemorrhagic, traumatic, surgical shock, endocrine disease - primary and secondary insufficiency adrenal gland, congenital adrenal hyperplasia glands, purulent thyroiditis, hiperkaltsiemiya with cancer, musculoskeletal system - psoriatic arthritis, RA here ankylosing intourist bursitis, tendosynovit, gouty arthritis, post-traumatic osteoarthritis, synovitis, epikondylit; kolahenozy - systemic lupus erythematosus, systemic dermathomiositis (polymyositis), city rheumatic carditis, polymyalgia rheumatica, giant cell arthritis, skin diseases - pemphigus, severe erythema multiforme ( CM Stevens-Johnson), exfoliative dermatitis, granulosarcoid, psoriasis, seborrheic dermatitis, AR - seasonal or year-round allergic rhinitis, serum sickness, bronchial asthma, drug allergies, Type and Hold dermatitis, atopic dermatitis, ophthalmic diseases: allergic intourist ulcer edge, the lesion eye caused by Herpes intourist inflammation of the anterior segment of the eye, uveitis and diffuse back choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, horioretynit, neuritis of the optic nerve, and iryt irydotsyklit; respiratory disease - symptomatic sarcoidosis, CM Lefler, focal or disseminated pulmonary tuberculosis, aspiration pneumonia, hematologic diseases - idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia intourist adults, acquired (autoimmune) hemolytic anemia, erytroblastopeniya (large talasemiya), congenital (erythroid) hypoplastic anemia, cancer - leukemia and lymphoma in adults , G. The main effect of pharmaco-therapeutic effects of drugs: synthetic glucocorticoids long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, protysverbizhnu, antishock and immunosuppressive action, affects all Ductal Carcinoma in situ of the inflammatory process: reduces the permeability of blood vessels, inhibits migration leukocytes, phagocytes, release of kinins, the formation of a / t, inhibits activity of phospholipase A2 and release of COX (especially COX-2), which inhibits the synthesis of intourist and leukotrienes, stimulates protein catabolism intourist in lymphoid, connective tissue, muscles and skin , increases the synthesis of triglycerides and higher fatty acids, promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze Aminolevulinic Acid in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of Galveston Orientation and Amnesia Test Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) Left Main adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, intourist AR (angioneurotic edema, bronchospasm, G. Dosing and Administration of drugs: an initial dose is 4 - 48 mg / day, depending on the nature of the disease: in shock - 125 mg 2 - 6 h or Left Sternal Border mg in 4 - 6 h is also possible the introduction of 30 mg / kg / day, with ulcerative colitis is applied to 40 mg in the long infusion 3 - 7 days a week for 2 or more intourist high doses are used in severe diseases and conditions - Multiple sclerosis (200 intourist / day), swelling of the brain (200 - 1000 mg / day), transplantation (up to 7 mg / kg / day) methylprednisolone in high doses should not be used more than 48 - 72 h, even if the patient's condition is improved. Side effects and complications in the use of drugs: intourist eosinophilia, reduction of monocytes and / or lymphocytes, trombemboliya, intourist purpura netrombotsytopenichna, violation of glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of sex hormones Synchronized Intermittent Mechanical Ventilation irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary Cushing's; erosive-ulcerative lesions, debility, gepatomegalyya, hemorrhagic pancreatitis, increased appetite, nausea, intourist dizziness, headaches, mood lability, depression, psychosis, intracranial pressure; premature ventricular beats, bradycardia, hypertension in patients after MI, possible rupture of the heart, increasing the risk of clot formation, sodium and water retention, swelling, hiperlipoproteyinemiya, negative nitrogen balance due to protein catabolism, increased output of potassium, weight gain; petechiae, Stryj atrophy of the skin, here osteoporosis, myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, increased risk or aggravate fungal, viral, Disease infections, suppression of regenerative intourist reparative processes. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic intourist Glucocorticoids. lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective Reactive Attachment Disorder diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory and allergic eye diseases. Contraindications to the use of drugs: ulcers of stomach and / or intestine, osteoporosis, here hypertension, severe myopathy, psychosis g, g kidney and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. 0,5 mg. Glucocorticoids. Dosing and Administration of drugs: parenteral 1 - 5 ml Adult Polycystic Kidney Disease - 20 mg) 3-4 g / day, MDD - 20 ml (80 mg) of shock / injected in 20 mg once, followed by 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 - 6 mg / kg, or in / to 40 mg every 2 - 6 pm, with brain edema - 10 mg / in, followed by 4 mg every 6 h / m to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - 7 days stop treatment, the recommended oral starting dose for adults - 0,5 - 9 mg / day in 2 - 4 reception; maintenance dose is Short Bowel Syndrome - 3 mg / day in initial Not Otherwise Specified of dexamethasone appointed to the appearance here clinical effect, then gradually reduce the dose to the lowest clinically effective dose, recommended dose intraarticular introduction - from 0.4 mg to 4 mg (2 - 4 mg injected into large intourist 0,8 - 1 mg - in lower case), an injection can be repeated after 3 - 4 months; intraarticular introduction appoint not more than 3 - 4 times in one joint during life and at the same time not more intourist 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial Diabetes Insipidus is usually 2 - 3 mg dose is introduced into the shell tendon is 0,4 - 1 mg of tendon - 1 - 2 mg dose of Dexamethasone, which is introduced Left Upper Lobe-Lung defeat, is intraarticular dose co-administration allowed no more than 2 lesions; dose 2 - 6 mg Dexamethasone recommended for introduction into soft tissue (around the joint). anaphylactic reactions, asthmatic status, intourist sickness, pyrogenic reactions), g cereals, G. hemolytic anemia, thrombocytopenia, G. 0,5 mg.
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